Use of botulinum toxin in pediatric spasticity (cerebral palsy)
Identifieur interne : 003A94 ( Main/Exploration ); précédent : 003A93; suivant : 003A95Use of botulinum toxin in pediatric spasticity (cerebral palsy)
Auteurs : Steffen Berweck [Allemagne] ; Florian Heinen [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-03.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Bontoxilysin, Botulinum Toxins (therapeutic use), Botulinum Toxins, Type A (therapeutic use), Brain (drug effects), Brain (pathology), Cerebral Palsy (drug therapy), Cerebral Palsy (pathology), Cerebral palsy, Child, Humans, Injections, Intramuscular, Magnetic Resonance Imaging (methods), Nervous system diseases, Neuromuscular Agents (therapeutic use), Pediatrics, Pediatrics (methods), Spasticity, Time Factors, Ultrasonography (methods), botulinum toxin, cerebral palsy, children, injection, multi‐level treatment, psoas muscle, sonography.
- MESH :
- chemical , therapeutic use : Botulinum Toxins, Botulinum Toxins, Type A, Neuromuscular Agents.
- drug effects : Brain.
- drug therapy : Cerebral Palsy.
- methods : Magnetic Resonance Imaging, Pediatrics, Ultrasonography.
- pathology : Brain, Cerebral Palsy.
- Humans, Injections, Intramuscular, Time Factors.
Abstract
Local injection of botulinum toxin (BT) is a well‐established treatment option for spastic movement disorders in children. BT blocks the release of acetylcholine from the axon terminal into the synaptic cleft of the motor endplate resulting in paresis of the injected musculature. Such localised, temporary chemodenervation of affected muscles can lead to functional gains and may improve the child's daily routine and rehabilitative care. We summarise state‐of‐the‐art treatment of spasticity in children with BT type A, addressing critical issues and introducing recent advances, such as sonography‐guided injection of BT and the distal injection of the psoas muscle without the need for general anaesthesia. First‐hand experience with BT type B in children is presented. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20088
Affiliations:
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Le document en format XML
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<term>Brain (drug effects)</term>
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<term>children</term>
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<front><div type="abstract" xml:lang="en">Local injection of botulinum toxin (BT) is a well‐established treatment option for spastic movement disorders in children. BT blocks the release of acetylcholine from the axon terminal into the synaptic cleft of the motor endplate resulting in paresis of the injected musculature. Such localised, temporary chemodenervation of affected muscles can lead to functional gains and may improve the child's daily routine and rehabilitative care. We summarise state‐of‐the‐art treatment of spasticity in children with BT type A, addressing critical issues and introducing recent advances, such as sonography‐guided injection of BT and the distal injection of the psoas muscle without the need for general anaesthesia. First‐hand experience with BT type B in children is presented. © 2004 Movement Disorder Society</div>
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